Social interaction affects cancer patients’ response to treatment | WPN World People News

How well cancer patients fared after chemotherapy was affected by their social interaction with other patients during treatment, according to a new study by researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, and the University of Oxford in the United Kingdom. Cancer patients were a little more likely to survive for five years or more after chemotherapy if they interacted during chemotherapy with other patients who also survived for five years or more. Patients were a little more likely to die in less than five years after chemotherapy when they interacted during chemotherapy with those who died in less than five years.

This image depicts a chemotherapy ward co-presence network. Circles are patients with color based on when they began chemotherapy (white corresponds to January, 2000, and red corresponds to December, 2008). Patients are connected when they were both in the chemotherapy ward at the same time more than expected by chance.

“People model behavior based on what’s around them,” said expert. “For example, you will often eat more when you’re dining with friends, even if you can’t see what they’re eating. When you’re bicycling, you will often perform better when you’re cycling with others, regardless of their performance.”

The researchers based their findings on electronic medical records data from 2000 to 2009 from two major hospitals in the United Kingdom’s National Health Service. The researchers examined the total time a patient spent with the same patients undergoing chemotherapy and their five-year survival rate. The five-year survival rate is the percentage of people who live at least five years after chemotherapy treatment is completed. For example, a five-year survival rate of 70 percent means that an estimated 70 out of 100 people are still alive five years after chemotherapy. They also reviewed a room schematic to confirm the assumption that patients were potentially positioned to interact.

“We had information on when patients checked in and out of the chemotherapy ward, a small intimate space where people could see and interact for a long period of time,” expert said. “We used ‘time spent getting chemotherapy in a room with others as a proxy for social connection.”

When patients were around those during chemotherapy who died in less than five years following chemotherapy, they had a 72 percent chance of dying within five years following their chemotherapy. The best outcome was when patients interacted with someone who survived for five years or longer: they had a 68 percent chance of dying within five years. The researchers’ model also predicted that if patients were isolated from other patients, they would have a 69.5 percent chance of dying within five years.

“A two percent difference in survival – between being isolated during treatment and being with other patients – might not sound like a lot, but it’s pretty substantial,” expert said. “If you saw 5,000 patients in nine years, that 2 percent improvement would affect 100 people.”

“It's the first research to investigate, on a large scale, how social context in a treatment setting can play a significant role in disease outcomes,” said expert. “As cancer care moves more towards targeted therapies based on genomic tumor assessments, NHGRI is interested in understanding how these social environmental factors might impact treatment efficacy.”

The researchers didn’t study why the difference occurred, but hypothesize that it may be related to stress response. “When you’re stressed, stress hormones such as adrenaline are released, resulting in a fight or flight response,” expert said. “If you are then unable to fight or fly, such as in chemotherapy, these hormones can build up.”

While the researchers also didn’t investigate the impact of visitors on cancer patients undergoing therapy, the effect would likely be similar, expert said.

“Positive social support during the exact moments of greatest stress is crucial,” expert said. “If you have a friend with cancer, keeping him or her company during chemotherapy probably will help reduce their stress. The impact is likely to be as effective, and possibly more effective, than cancer patients interacting with other cancer patients.”

Source: U.S. National Institutes of Health