Human Connectome Project Marks its First Phase | WPN World People News

Scans of an individual’s brain activity are emerging as powerful predictive tools, thanks to the Human Connectome Project (HCP), an initiative of the National Institutes of Health. Such individual differences were often discarded as “noise” – uninterpretable apart from group data. Now, recently reported studies based on HCP neuroimaging and psychological data show that individual differences in brain connectivity can reliably predict a person’s behavior. Such scans might someday help clinicians personalize diagnosis and treatment of mental disorders, say researchers.

One study found that an individual’s unique resting state connectivity “fingerprint” can accurately predict fluid intelligence. Another developed a model that similarly predicted individuals’ performance on a variety of tasks, including reading and decision-making. Notably, no brain scans or psychological tests were required specifically for these studies; instead, the researchers drew upon an unprecedented trove of shared data from more than a thousand subjects made available by the HCP.

In 2010, NIH awarded two HCP grants to map the human brain’s connections in high resolution. The aim was to understand the connections of the healthy human brain to establish a baseline that would help identify connectivity abnormalities in brain disorders. The grants supported two research consortia, one led by researchers at Washington University, in St. Louis, and the University of Minnesota; the other led by investigators at Massachusetts General Hospital (MGH)/Harvard University, Boston, and the University of California Los Angeles (UCLA).

The MGH/UCLA consortium built a custom “Connectom” scanner with advanced diffusion MRI technology that can visualize the brain’s networks in 10-fold higher detail than conventional scanners. At least two other leading research centers have recently adopted the HCP-designed high-powered diffusion imaging scanners – which boost resolving power via magnetically stronger copper coils, called gradients.

In parallel, researchers at Washington University and the University of Minnesota led a multi-institution consortium that comprehensively mapped long-distance brain connections and their variability in 1,200 healthy adults (twins and their non-twin siblings), using both MRI and magnetoencephalography. By pairing studies of structural and functional brain connectivity with extensive behavioral and heritability measures, the project has provided data about brain connectivity, its relationship to behavior, and contributions of environmental and genetic factors to individual differences in brain circuitry.

Technical advances achieved during the project have transformed the field – for example, enabling much more efficient data collection by dramatically shortening the duration of scans while maintaining high-resolution images. The wealth of data gathered has been shared with the wider neuroimaging community via a data archive supported by NIH. These user-friendly tools for data mining, analysis, and visualization are enabling discoveries such as those on the predictive power of individual scan data, noted above.

Source: U.S. National Institute of Mental Health