Generic Hepatitis C Drugs as Effective as Pricey Brand Names: Study
Inexpensive antivirals could be a game-changer in many countries, researchers say.
Low-cost generic antiviral drugs are as effective and safe as more expensive brand-name drugs in treating people with hepatitis C, researchers report.
In many countries, people don't have access to a course of brand-name direct-acting antiviral drugs due to the high cost -- as much as $94,000 a patient, the researchers explained.
However, mass-produced generic versions are available for less than 1 percent of the retail price of the brand-name drugs, they added.
"Our interim data suggests a potential solution for hepatitis C patients in areas where treatment access has been restricted as a result of the high prices demanded for branded treatment," said expert.
The study of patients in the United States, Canada, Africa, Australia, Europe and Southeast Asia found that generic direct-acting antiviral drugs sofosbuvir (Sovaldi), ledipasvir, daclatasvir (Daklinza) and ribavirin (Rebetol) were as effective as brand-name versions.
A full course of brand-name direct-acting antiviral medication that costs $94,000 a patient in the United States can be obtained in generic form for less than $1,000. And, a 12-week course of treatment could cost as little as $200 in coming years, the researchers said.
"At the price level of generic direct-acting antivirals, treating the entire global hepatitis C epidemic could be financially feasible. Furthermore, if a patient is cured of hepatitis C, there is evidence for improved survival and lower risks of liver cancer and liver cirrhosis," expert said. Expert added that cured patients could return to work, delivering further economic benefits to society.
Another expert said there is a clear role for generic treatments such as these for people with hepatitis C.
"The implications of increased availability of these drugs could be enormous, presenting more people with the possibility of a 'cure' for what is often a debilitating condition," expert said.
Hepatitis C is a virus that can infect the liver, leading to inflammation, scarring and liver cancer.
Source: U.S. Dept. of Health & Human Services
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