Keytruda May Help Fight Tough-to-Treat Lung Cancer | WPN World People News

The immune therapy drug Keytruda (pembrolizumab) may extend the lives of people with advanced lung cancer, a new study finds.

Keytruda is commonly used to treat other tumor types, and made headlines recently after it helped former President Jimmy Carter fight off brain cancer.

In this study, researchers compared Keytruda to the chemotherapy drug docetaxel in more than 1,000 patients with non-small cell lung cancer. All of the patients were battling tumors that had progressed even after chemotherapy.

Non-small cell lung cancer is the leading form of the disease.

All of the patients' tumors produced a protein called PD-L1, which can shield the tumor from immune system attack, according to a expert.

Among patients with the highest amounts of PD-L1, those who received Keytruda lived twice as long as those who received docetaxel alone -- 14.9 months vs. 8.2 months, Herbst's team found. Patients with low levels of PD-L1 also benefited from Keytruda.

Treatment-linked side effects were less in patients given Keytruda versus those who took docetaxel, the study found.

There might be one drawback to Keytruda, however: cost. A year's supply of the drug carries a price tag of about $150,000.

The findings suggest that the drug might be offered earlier to patients with a particular lung tumor profile, said expert.

"I believe we should treat patients with the best available drugs as soon as possible. Now that we have learned which patients are most likely to benefit from the anti-PD-L1 strategy, we could begin moving this drug to the earlier setting stages," expert said.

"In this direction, I am eager to see the results of ongoing studies testing [Keytruda] in the first-line setting and as an adjuvant after surgery to hopefully reduce high rates of lung cancer recurrence," expert added.

Another expert agreed that the findings may mark an advance against lung cancer.

"This is a fascinating development in cancer treatment that uses targeted immunotherapy instead of standard chemotherapy," noted expert.

"This is being examined in other cancers as well," expert added, "and may represent the dawn of new immune-based approaches to cancer."

In October, the U.S. Food and Drug Administration approved Keytruda for the treatment of patients with advanced non-small cell lung cancer whose tumors express PD-L1 and whose cancer progressed while or after receiving platinum-containing chemotherapy.

Source: HealthDay News