Death Toll From Meningitis Outbreak Now Stands at 7 | WPN World People News

Health officials in 23 states are trying to track down patients who received steroid injections for routine back pain that may have been contaminated with a deadly type of fungus-related meningitis linked to seven deaths and at least 64 cases of illness in nine states.

All of the patients were injected with methylprednisolone acetate, a steroid drug that investigators suspect was contaminated with a fungus usually found in leaf mold.

The drug was manufactured by a specialty pharmacy which last week voluntarily recalled three lots of the steroid. It has since shut down operations and stopped distributing its products.

The number of meningitis cases had risen to 64 in nine states by Saturday afternoon, and the number of deaths had climbed to seven.

The CDC on late Friday released a list of the approximately 75 health-care facilities that received contaminated product.

The CDC offered the following state-by-state breakdown of cases on Saturday: Florida: 4 cases; Indiana: 5 cases; Maryland: 3 cases, including 1 death; Michigan: 8 cases, including 2 deaths; Minnesota: 1 case; North Carolina: 2 cases; Ohio: 1 case; Tennessee: 29 cases, including 3 deaths; Virginia: 11 cases, including 1 death.

U.S. health officials said they expect to see more cases of the rare type of meningitis, which is not contagious, because symptoms can take a month or more to appear. All of the infected patients received the medication.

Infected patients have developed a variety of symptoms approximately one to four weeks following their injection. Symptoms include fever, new or worsening headache, nausea, and "new neurological deficit (consistent with deep brain stroke). Some of these patients' symptoms were very mild in nature. Cerebrospinal fluid from these patients has shown findings consistent with meningitis.

The New England Compounding Center last week voluntarily recalled the following lots of methylprednisolone acetate:

■ Methylprednisolone Acetate (PF) 80 mg/ml Injection, Lot #05212012@68, BUD 11/17/2012

■ Methylprednisolone Acetate (PF) 80 mg/ml Injection, Lot #06292012@26, BUD 12/26/2012

■ Methylprednisolone Acetate (PF) 80 mg/ml Injection, Lot #08102012@51, BUD 2/6/2013

Doctors should immediately contact patients who have had an injection from any of the three lots to see if they're having any symptoms. Although all cases of meningitis detected so far occurred after injections with products from these three lots, the CDC and the U.S. Food and Drug Administration recommended that health-care professionals not use any products produced by the New England Compounding Center until more information is available.

Patients who have had a steroid injection since July, and have any of the following symptoms, should talk to their doctor as soon as possible:

■ Worsening headache,
■ Fever,
■ Sensitivity to light,
■ Stiff neck,
■ New weakness or numbness in any part of your body,
■ Slurred speech.

The suspected steroid was shipped to 23 states, Park said.
A Nashville, Tenn., clinic reportedly received the largest shipment of the steroid.

The steroid procedure -- called lumbar epidural steroid injection -- is a common treatment for back pain that has not responded to medicines, physical therapy or other nonsurgical treatments. Although it is usually safe, experts now urge anyone who has recently had the procedure and experiences severe headache, fever, chills or nausea to notify a doctor immediately.

From the time of the injection until symptoms appear may be a month or more. Not everyone who got the steroid injection will develop meningitis -- an inflammation of tissue surrounding the brain and spinal cord -- but it's hard to know how many will.

Some of the symptoms associated with this rare form of meningitis are unusual. One of the things we are just learning about these patients is that they can present with minor stroke-like symptoms, which would include slurred speech and unsteady gait.

Stroke is not usually associated with either bacterial or viral meningitis. Infected patients must receive intravenous drugs in a hospital setting.

Treatment can take weeks if not months, because these infections are difficult to treat. And the drugs can have severe side effects, including affecting kidney function.

While some infected patients are doing well, others are in intensive care and may die. Although the steroid is the primary target of investigation, health officials haven't ruled out the antiseptic and anesthetic used during the injections as a possible cause of the outbreak.

The meningitis outbreak underscores the importance of sterilization procedures in intravenous and intramuscular shots.

Source: U.S. Dept. of Health & Human Services