Differences Seen in Lung Microbes of Cystic Fibrosis Patients
More diversity noted in tissue samples of healthy people.
Marked differences exist between the communities of bacteria in the lungs of healthy people and those with cystic fibrosis, according to a new study.
The findings could prove important in the treatment of cystic fibrosis and other lung diseases, according to the researchers at Stanford University and Lucile Packard Children's Hospital. Cystic fibrosis is an inherited disease of the body's mucus glands.
The lung is not a sterile organ. This research confirmed a long-held suspicion that a forest of microbes exists in both healthy and diseased lungs.
The findings also suggest that microbes play a role in preserving lung health.
The researchers analyzed sputum samples from 16 cystic fibrosis patients and nine healthy people. Also analyzed tissue from the removed lungs of seven lung transplant patients -- three who had cystic fibrosis and four who had other lung diseases.
In general, healthy people had more diversity in their lung microbe communities than cystic fibrosis patients.
The tendency toward decreased diversity can be metaphorically viewed as the same phenomenon that might happen in a rainforest. When the ecosystem of a rainforest is disturbed and one organism predominates, it undermines a carefully constructed balance and causes disturbances in the overall ecosystem. It's reasonable to assume something similar could happen in the lung microbiome, where pathogenic bacteria may out-compete organisms that may play a salutary, health-affirming role.
The researchers also found that healthy people had a larger percentage of two groups of bacteria, while cystic fibrosis patients had a larger percentage of another type of bacteria. Healthy people also had a larger proportion of bacteria that had never been grown in a lab.
Source: HealthDay News
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