Science

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Fluorescent-based tool reveals how medical nanoparticles biodegrade in real time: May inform development of versatile drug carriers for therapeutic uses in patients

Nanoparticles have been heralded as a potential "disruptive technology" in biomedicine, a versatile platform that could supplant conventional technologies, both as drug delivery vehicles and diagnostic tools.

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Nanoparticle disassembly causes a shift in the fluorescence pattern.

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NASA Seeks External Concepts for Mission to Oceanic Jovian Moon

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This image shows two views of the trailing hemisphere of Jupiter's ice-covered satellite, Europa. The left image shows the approximate natural color appearance of Europa. The image on the right is a false-color composite version combining violet, green and infrared images to enhance color differences in the predominantly water-ice crust of Europa.

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NASA Puzzles Out Ozone's Ups and Downs

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Astronauts aboard the International Space Station captured this photograph of Earth's atmospheric layers on July 31, 2011, revealing the troposphere (orange-red) to the stratosphere and above. Earth-observing instruments in space allow scientists to better understand the chemistry and dynamics occurring within and between these layers.

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NASA's Spitzer and WISE Telescopes Find Close, Cold Neighbor of Sun

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This artist's conception shows the object named WISE J085510.83-071442.5, the coldest known brown dwarf. This cool star-like body is as frosty as the North Pole (or between minus 54 and 9 degrees Fahrenheit). It is also the fourth closest system to our sun, at 7.2 light-years from Earth.

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Simple Method Suggested for Hormone Determination by Using Nanoparticles

Iranian researchers from Khwarizmi University proposed a sensitive, accurate, repeatable and highly cost-effective method to measure tiny amounts of hormones in biological samples.

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Drill Here? NASA's Curiosity Mars Rover Inspects Site

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NASA's Curiosity Mars rover has driven within robotic-arm's reach of the sandstone slab at the center of this April 23 view from the rover's Mast Camera. The rover team plans to have Curiosity examine a target patch on the rock, called "Windjana," to aid a decision about whether to drill there.

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Gold nanoparticles help target, quantify breast cancer gene segments in a living cell

Alternative messenger RNA (mRNA) splicing is a fundamental process of gene regulation, and errors in RNA splicing are known to be associated with a variety of different diseases. However, there is currently a lack of quantitative technologies for monitoring mRNA splice variants in cells. Here, we show that a combination of plasmonic dimer probes and hyperspectral imaging can be used to detect and quantify mRNA splice variants in living cells.

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A single gold nanoparticle, or monomer, appears green when illuminated (top left), while a pair of gold nanoparticles bound to an mRNA splice variant, or dimer, appears reddish (top right). Monomers and dimers also scatter light differently, as shown in the graph above.

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Atomic switcheroo explains origins of thin-film solar cell mystery

Treating cadmium-telluride (CdTe) solar cell materials with cadmium-chloride improves their efficiency, but researchers have not fully understood why. Now, an atomic-scale examination of the thin-film solar cells led by the Department of Energy's Oak Ridge National Laboratory has answered this decades-long debate about the materials' photovoltaic efficiency increase after treatment.

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Cross-sectional electron beam-induced current maps show the difference in cadmium telluride solar cells before (pictured above) and after (below) cadmium chloride treatment. The increased brightness after treatment indicates higher current collection at the grain boundaries.

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Berkeley Lab Researchers Demonstrate First Size-based Chromatography Technique for the Study of Living Cells

Using nanodot technology, Berkeley Lab researchers have demonstrated the first size-based form of chromatography that can be used to study the membranes of living cells. This unique physical approach to probing cellular membrane structures can reveal information critical to whether a cell lives or dies, remains normal or turns cancerous, that can't be obtained through conventional microscopy.

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With size-based chromatography, a hexagonally ordered array of gold nanoparticles is fabricated onto a hybrid live cell-supported membrane. Membrane components move freely through the array provided they don’t exceed its physical dimensions. This reveals organizational aspects of the membrane environment unobservable by other techniques.

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Nanoreporters tell 'sour' oil from 'sweet': Rice University's hydrogen sulfide nanoreporters gather intel on oil before pumping

Scientists at Rice University have created a nanoscale detector that checks for and reports on the presence of hydrogen sulfide in crude oil and natural gas while they're still in the ground.

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Fluorescent nanoreporters created at Rice University can tell oil producers how "sour" a reservoir is based on its hydrogen sulfide content.

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