Science

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Injectable ‘Smart Sponge’ Holds Promise for Controlled Drug Delivery

A glucose-responsive closed-loop insulin delivery system represents the ideal treatment of type 1 diabetes mellitus. In this study, we develop uniform injectable microgels for controlled glucose-responsive release of insulin. Monodisperse microgels (256 +/= 18 ?m), consisting of a pH-responsive chitosan matrix, enzyme nanocapsules, and recombinant human insulin, were fabricated through a one-step electrospray procedure. Glucose-specific enzymes were covalently encapsulated into the nanocapsules to improve enzymatic stability by protecting from denaturation and immunogenicity as well as to minimize loss due to diffusion from the matrix. The microgel system swelled when subjected to hyperglycemic conditions, as a result of the enzymatic conversion of glucose into gluconic acid and protonation of the chitosan network. Acting as a self-regulating valve system, microgels were adjusted to release insulin at basal release rates under normoglycemic conditions and at higher rates under hyperglycemic conditions. Finally, we demonstrated that these microgels with enzyme nanocapsules facilitate insulin release and result in a reduction of blood glucose levels in a mouse model of type 1 diabetes.

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In this image, the “smart sponges” are exposed to high glucose levels and are swelling to release insulin.

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Snow in an Infant Planetary System

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A snow line has been imaged in a far-off infant planetary system for the very first time. The snow line, located in the disc around the Sun-like star TW Hydrae, promises to tell us more about the formation of planets and comets, the factors that decide their composition, and the history of the Solar System.

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Paper-thin e-skin responds to touch, holds promise for sensory robotics and interactive environments

A new milestone by engineers at the University of California, Berkeley, can help robots become more touchy-feely, literally.

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In this artistic illustration of an interactive e-skin device, the intensity of the emitted light corresponds to how hard the surface is pressed.

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CERN experiments put Standard Model to stringent test – UK reaction here

New results being presented at the EPS-HEP conference in Stockholm, Sweden, this afternoon (19th July 2013) have put the Standard Model of particle physics to one of its most stringent tests to date. The CMS and LHCb experiments at CERN’s Large Hadron Collider will present measurements of one of the rarest measureable processes in physics: the decay of a Bs (pronounced B-sub-s) particle into two muons.

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New nanoscale imaging method finds application in plasmonics

Researchers from the National Institute of Standards and Technology (NIST) and the University of Maryland have shown how to make nanoscale measurements of critical properties of plasmonic nanomaterials—the specially engineered nanostructures that modify the interaction of light and matter for a variety of applications, including sensors, cloaking (invisibility), photovoltaics and therapeutics.

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Infrared laser light (purple) from below a sample (blue) excites ring-shaped nanoscale plasmonic resonator structures (gold). Hot spots (white) form in the rings' gaps. In these hot spots, infrared absorption is enhanced, allowing for more sensitive chemical recognition. A scanning AFM tip detects the expansion of the underlying material in response to absorption of infrared light.

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Disks Don't Need Planets to Make Patterns

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Debris disks around stars naturally form complex structures without the presence of a planet. This image shows the dust density and the growth of structure in a simulated disk, which extends about 100 times farther from its star than Earth's orbit around the sun. At left, the disk is seen from a 24-degree angle; at right, it's face-on. Lighter colors show greater dust concentrations.

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Using pressure to swell pores, not crush them

More than a decade ago, Thomas Vogt and Yongjae Lee, then colleagues at Brookhaven National Laboratory, uncovered a counter-intuitive property of zeolites. When they put these porous minerals in water, and then put the water under high pressure, the tiny cavities within the zeolites actually grew in size.

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Smart anticancer nanofibers: Setting treatments to work together

MANA researchers report that incorporating magnetic nanoparticles and an anticancer drug into crosslinked polymer nanofibers presents a twofold treatment for fighting cancer with diminished side effects.

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Design concept for a smart hyperthermia nanofiber system that uses magnetic nanoparticles (MNPs) dispersed in temperature-responsive polymers. Anticancer drug, doxorubicin (DOX), is also incorporated into the nanofibers. The nanofibers are chemically crosslinked. First, the device signal (alternating magnetic field, AMF) is turned 'on' to activate the MNPs in the nanofibers. Then, the MNPs generate heat to collapse the polymer networks in the nanofiber, allowing the 'on-off' release of DOX. Both the generated heat and released DOX induce apoptosis of cancer cells by hyperthermic and chemotherapeutic effects, respectively.

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A new form of carbon: Grossly warped 'nanographene': Bucking planarity, contorted sheets of graphene alter physical, optical and electronic properties of new material

Chemists at Boston College and Nagoya University in Japan have synthesized the first example of a new form of carbon.

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Chemists at Boston College and Nagoya University in Japan have synthesized the first example of a new form of carbon. The new material consists of multiple identical pieces of "grossly warped graphene," each containing exactly 80 carbon atoms joined together in a network of 26 rings, with 30 hydrogen atoms decorating the rim. Because they measure slightly more than a nanometer across, these individual molecules are referred to generically as "nanocarbons."

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Imaging Electron Pairing in a Simple Magnetic Superconductor: Findings and resulting theory could reveal mechanism behind zero-energy-loss current-carrying capability

In the search for understanding how some magnetic materials can be transformed to carry electric current with no energy loss, scientists at the U.S. Department of Energy's Brookhaven National Laboratory, Cornell University, and collaborators have made an important advance: Using an experimental technique they developed to measure the energy required for electrons to pair up and how that energy varies with direction, they've identified the factors needed for magnetically mediated superconductivity-as well as those that aren't.

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The height above the plane of this diagram represents the energy required to break a superconducting pair of electrons into separate heavy fermions traveling in different directions (as determined from the quasiparticle scattering patterns). The maximum height is at the locations predicted if the "glue" holding the electron pairs together is magnetism.

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