Scientists Succeed in Simultaneous Determination of Acetaminophen, Codeine in Drug Samples

Iranian chemists from Arak University used carbon nanotubes and succeeded in the production of a sensor that is able to simultaneously determine very tiny amounts of acetaminophen and codeine in drugs without any need to very time-consuming steps for the preparation of the sample.

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2014-04-10

Having simple and cheap production method, the sensor can be used in pharmaceutical industries for medical purposes.

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Results of the research showed that the produced sensor did not need sample preparation, and it had high sensitivity and selectivity in simultaneous determination of acetaminophen and codeine. Among other characteristics of the research, mention can be made of low production cost, repeatability, rapid response and high stability. In addition, the disturbing species have very small effect on the sensor during the determination.

The researchers employed successfully the produced sensor in detecting medical samples and human blood serum.

In this research and after the production of glassy carbon electrode modified with multi-walled carbon nanotubes, the researchers obtained optimum conditions for detection process such as the type of buffer, pH value of the solution and doping time. Cyclic voltammetry, differential pulse voltammetry, and chronoamperometry methods were used to study the product. Finally, the produced sensor was used under the obtained optimum conditions to simultaneously detect the two types of drugs in biological samples and medications.

The use of nanoparticles, including the use of carbon nanotubes in this sensor, increases electrode surface, electron transfer rate and other catalytic activities of the sensor. It also increases electric currents being measured, and therefore, increases the sensitivity and improves the performance of the product.

Source: Nanotechnology Now

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