Health

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NIH scientists describe potential antibody approach for treating multidrug-resistant Klebsiella pneumoniae

Promising concept may lead to an alternative to antibiotics.

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Klebsiella bacteria.

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NIH scientists search for the clocks behind aging brain disorders

Study of flies suggests neurodegenerative disorders may speed up aging process.

To understand the link between aging and neurodegenerative disorders such as Alzheimer’s disease, scientists from the National Institutes of Health compared the genetic clocks that tick during the lives of normal and mutant flies. They found that altering the activity of a gene called Cdk5 appeared to make the clocks run faster than normal, and the flies older than their chronological age. This caused the flies to have problems walking or flying later in life, to show signs of neurodegeneration, and to die earlier.

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UN anti-drug conference offers ‘opportunity to chart a better and balanced path’ forward – UN chief

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Yury Fedotov, the Executive Director of the UN Office on Drugs and Crime (UNODC) addresses the 61st session of the Commission on Narcotic Drugs.

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CRISPR helps find new genetic suspects behind ALS/FTD

Study provides roadmap for using CRISPR to investigate neurological disorders.

NIH-funded researchers at Stanford University used the gene editing tool CRISPR-Cas9 to rapidly identify genes in the human genome that might modify the severity of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) caused by mutations in a gene called C9orf72. The results of the search, uncovered a new set of genes that may hasten neuron death during the disease.

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NIH experts call for transformative research approach to end tuberculosis

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Scanning electron micrograph of Mycobacterium tuberculosis bacteria, which cause TB.

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Monoclonal antibodies crucial to fighting emerging infectious diseases, say NIH officials

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Ebola virus particles (red) on a larger cell. ZMAPP, a potential treatment for Ebola, includes a cocktail of monoclonal antibodies.

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NIAID scientists assess transmission risk of familial human prion diseases to mice

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Prion protein fibrils.

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This World Kidney Day, shine a spotlight on women’s health

NIH statement from Dr. Griffin P. Rodgers, Director, National Institute of Diabetes and Digestive and Kidney Diseases.

Chronic kidney disease affects more women than men, but most people with this condition don’t know they have it. This World Kidney Day, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, joins organizations around the world in urging women to take action to prevent kidney disease — for themselves and their loved ones.

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Antiviral drug not beneficial for reducing mother-to-child transmission of hepatitis B when added to existing preventatives

NIH-funded study observes no significant reduction of infection rates at age 6 months.

Tenofovir disoproxil fumarate (TDF), an antiviral drug commonly prescribed to treat hepatitis B infection, does not significantly reduce mother-to-child transmission of hepatitis B virus when taken during pregnancy and after delivery, according to a phase III clinical trial in Thailand funded by the National Institutes of Health.

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The brain’s internal clock continually takes its temperature

NIH-funded research study of flies provides insight into how brain circuits regulate sleep.

Circuits in the brain act as an internal clock to tell us it is time to sleep and to control how long we then stay asleep. A new study in flies suggests a part of that clock constantly monitors changes in external temperature and integrates that information into the neural network controlling sleep. The study was supported by the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health.