Health

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Gene regulators work together for oversized impact on schizophrenia risk

Modeled gene expression changes match those found in patients’ brains.

Researchers have discovered that gene expression regulators work together to raise an individual’s risk of developing schizophrenia. Schizophrenia-like gene expression changes modeled in human neurons matched changes found in patients’ brains. The researchers report on their findings on Sept 23.

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Study assesses asthma treatment options in African American children and adults

Use of long-acting bronchodilators had no impact for some African American children.

A new study of African Americans with poorly controlled asthma, found differences in patients’ responses to commonly used treatments. Contrary to what researchers had expected, almost half of young children in the study responded differently than older children and adults, and than white children in prior studies.

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More women and children survive today than ever before – UN report

Despite progress, a pregnant woman or newborn dies somewhere in the world every 11 seconds

More women and their children are surviving today than ever before, according to new child and maternal mortality estimates released on Sept.19 by United Nations groups* led by UNICEF and the World Health Organization (WHO).

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The brain may actively forget during dream sleep

NIH-funded study suggests REM sleep may prevent information overload.

Rapid eye movement, or REM, sleep is a fascinating period when most of our dreams are made. Now, in a study of mice, a team of Japanese and U.S. researchers show that it may also be a time when the brain actively forgets. Their results suggest that forgetting during sleep may be controlled by neurons found deep inside the brain that were previously known for making an appetite stimulating hormone.

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ALS gene may be a hitchhiker’s guide to the neuron

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Researchers discovered that annexin A11, a gene linked to a rare form of ALS, may play a critical role in the transport of RNA-encoded housekeeping instructions throughout neurons by hitching RNA granules onto traveling lysosomes and that disease-causing mutations prevent hitchhiking.

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Teen e-cigarette use doubles since 2017

Researchers sound alarm on potential health effects of vaping.

Data from the 2019 Monitoring the Future Survey of eighth, 10th and 12th graders show alarmingly high rates of e-cigarette use compared to just a year ago, with rates doubling in the past two years. University of Michigan, Ann Arbor, scientists who coordinate and evaluate the survey to notify public health officials working to reduce vaping by teens.

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Study quantifies impact of NIH-sponsored trials on clinical cancer care

A new study shows that nearly half of phase 3 cancer clinical trials carried out by the National Cancer Institute (NCI)-sponsored SWOG Cancer Research Network, one of five groups in NCI’s National Clinical Trials Network (NCTN), were associated with clinical care guidelines or new drug approvals. NCI is part of the National Institutes of Health.

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NIH-funded study suggests teen girl ‘night owls’ may be more likely to gain weight

Teen girls — but not boys — who prefer to go to bed later are more likely to gain weight, compared to same-age girls who go to bed earlier, suggests a study funded by the National Institutes of Health.

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Prolonged antibiotic treatment may alter preterm infants’ microbiome

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Scanning electron micrograph of neutrophil ingesting methicillin-resistant Staphylococcus aureus bacteria.

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New research collaboratory designed to spur innovation and improve dementia care

NIH-funded initiative involves health care systems to test interventions in real-world settings.

To spur innovation to meet the challenges of complex care management for people with Alzheimer’s disease and related dementias (AD/ADRD) and their families, the National Institute on Aging (NIA), part of the National Institutes of Health, has funded a new effort designed to test care interventions in real-world settings. Brown University, Providence, Rhode Island, will partner with Hebrew Senior Life, a Harvard Medical School Affiliate, Roslindale, Massachusetts, to manage the Imbedded Pragmatic AD/ADRD Clinical Trials (IMPACT) Collaboratory with funding from NIA that is expected to total $53.4 million over five years. IMPACT Collaboratory researchers will team with scientists at other universities with health care and long-term care systems to guide research to develop and test novel ways to care for people with AD/ADRD.